Kolaviron improves behavioral outcomes and cortico-hippocampal morphology in mice following cuprizone neurotoxicity
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چکیده
منابع مشابه
Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function.
Acrylamide intoxication produces peripheral neuropathy characterized by weakness and ataxia in both humans and experimental animals. Previous studies on animals of different ages and species indicate that the longest and largest nerves are affected earlier with the major pathology in the terminal parts of axons, i.e., distal axonopathy. However, several issues have remained elusive; for example...
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Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant and found in the environment and in biota. The neurotoxicity of PFOS has received much concern among its various toxic effects when given during developing period of brain. However, little is known about the neurotoxic effects and potential mechanisms of PFOS in the mature brain. Our study demonstrated the neurotoxicity and the potentia...
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Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to potentially addictive drugs, particularly anti-diarrhoea opioid drugs such as diphenoxylate or difenoxin. The aim of this study was to investigate spatial memory and motor changes associated with varying doses (5 and 10 mg/kg body weight) ingestion of atropine, as well as it...
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Background and Aims: This study examined sub-chronic effects of Methamphetamine (METH) on the stereological parameters in the Cornu Ammonis (CA) of the hippocampus in adult mice. Materials and Methods: Fifteen adult male mice, eight weeks old, were randomly divided into three groups: receive saline (controls), or low-dose (LD) 2.5 mg/kg METH, or high-dose (HD) 25 mg/kg METH, via daily intrap...
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Intracerebral hemorrhage (ICH), the most common form of hemorrhagic stroke, exhibits the highest acute mortality and the worst long-term prognosis of all stroke subtypes. Unfortunately, treatment options for ICH are lacking due in part to a lack of feasible therapeutic targets. Inflammatory activation is associated with neurological deficits in pre-clinical ICH models and with patient deteriora...
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ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.1548